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Home / Archives for Borges JP

Borges JP

Doxorubicin vs. ladirubicin: methods for improving osteosarcoma treatment.

  • Autores: Borges JP, Dias SJ, Ferreira IM, Novo C, Soares PI
  • Ano de Publicação: 2012
  • Journal: Mini-Reviews in Medicinal Chemistry
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Doxorubicin+vs.+ladirubicin%3A+methods+for+improving+osteosarcoma+treatment

Osteosarcoma is the most common primary bone tumor in children and adolescents, with a 5-year disease free survival rate of 70%. Current chemotherapy regimens comprise a group of chemotherapeutic agents in which doxorubicin is included. However, tumor resistance to anthracyclines and cardiotoxicity are limiting factors for its usage.
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Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling

  • Autores: Borges JP, Ferreira IMM, Novo C, Silva JC, Soares PIP, Sousa AI
  • Ano de Publicação: 2016
  • Journal: Carbohydrate Polymers
  • Link: http://www.sciencedirect.com/science/article/pii/S0144861716302570

In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH.
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Towards the development of multifunctional chitosan-based iron oxide nanoparticles: Optimization and modelling of doxorubicin release

  • Autores: Borges JP, Ferreira IM, Novo CM, Soares PI, Sousa AI
  • Ano de Publicação: 2016
  • Journal: Carbohydr Polym
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/27561489

In the present work composite nanoparticles with a magnetic core and a chitosan-based shell were produced as drug delivery systems for doxorubicin (DOX). The results show that composite nanoparticles with a hydrodynamic diameter within the nanometric range are able to encapsulate more DOX than polymeric nanoparticles alone corresponding also to a higher drug release. Moreover the synthesis method of the iron oxide nanoparticles influences the total amount of DOX released and a high content of iron oxide nanoparticles inhibits DOX release. The modelling of the experimental results revealed a release mechanism dominated by Fickian diffusion.
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Iron oxide nanoparticles stabilized with a bilayer of oleic acid for magnetic hyperthermia and MRI applications

  • Autores: Borges JP, Carvalho A, Coutinho JT, Ferreira IMM, Laia CAT, Novo C, Pereira LCJ, Soares PIP
  • Ano de Publicação: 2016
  • Journal: Applied Surface Science
  • Link: http://www.sciencedirect.com/science/article/pii/S0169433216309709

Iron oxide nanoparticles (Fe3O4, IONPs) are promising candidates for several biomedical applications such as magnetic hyperthermia and as contrast agents for magnetic resonance imaging (MRI). However, their colloidal stability in physiological conditions hinders their application requiring the use of biocompatible surfactant agents.
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Application of hyperthermia for cancer treatment: recent patents review.

  • Autores: Borges JP, Ferreira IM, Igreja RA, Novo C, Soares PI
  • Ano de Publicação: 2012
  • Journal: Recent Patents on Anti-Cancer Drug Discovery
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/21854362

Cancer is one of the main causes of death in the world and its incidence increases every day. Current treatments are insufficient and present many breaches. Hyperthermia is an old concept and since early it was established as a cancer treatment option, mainly in superficial cancers.
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One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

  • Autores: Borges JP, Echeverria C, IFerreira I, Novo C, Pereira L, Robalo A, Soares P
  • Ano de Publicação: 2015
  • Journal: Materials and Design
  • Link: http://www.sciencedirect.com/science/article/pii/S0264127515302392

The incorporation of magnetic nanoparticles into poly(N-isopropylacrylamide) (PNIPAAm) and chitosan microgels gives rise to hybrid systems that combine the microgels swelling capacity with the interesting features presented in magnetic nanoparticles. The presence of chitosan that act as surfactant for magnetic nanoparticles provides a simplistic approach which allows the encapsulation of magnetic nanoparticles without any previous surface modification.
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