Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling

In the present work, two drug delivery systems were produced by encapsulating doxorubicin into chitosan and O-HTCC (ammonium-quaternary derivative of chitosan) nanoparticles. The results show that doxorubicin release is independent of the molecular weight and is higher at acidic pH (4.5) than at physiological pH.
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Phylogeographical footprint of colonial history in the global dispersal of human immunodeficiency virus type 2 group A.

Autores: Camacho RJ, de Sousa JD, Erasmus S, Faria NR, Goncalves MF, Goubau P, Hodges-Mameletzis I, Jallow S, Lemey P, Paolucci S, Pieniazek D, Rodés B, Ruelle J, Silva JC, Soriano V, Suchard MA, Taveira N, Treviño A, Vandamme AM, Xu L
Ano de Publicação: 2012
Journal: Journal of General Virology
Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Phylogeographical+footprint+of+colonial+history+in+the+global+dispersal+of+human+immunodeficiency+virus+type+2+group+A

Human immunodeficiency virus type 2 (HIV-2) emerged in West Africa and has spread further to countries that share socio-historical ties with this region. However, viral origins and dispersal patterns at a global scale remain poorly understood. Here, we adopt a Bayesian phylogeographic approach to investigate the spatial dynamics of HIV-2 group A (HIV-2A) using a collection of 320 partial pol and 248 partial env sequences sampled throughout 19 countries worldwide.
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Silva JC

Chitosan-based nanoparticles as drug delivery systems for doxorubicin: optimization and modelling

Phylogeographical footprint of colonial history in the global dispersal of human immunodeficiency virus type 2 group A.

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