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Home / Archives for Martins C

Martins C

A new cloning system based on the OprI lipoprotein for the production of recombinant bacterial cell wall-derived immunogenic formulations.

  • Autores: Alves S, Basto AP, Cornelis P, Leitão A, Martins C, Piedade J, Ramalho R, Soares H
  • Ano de Publicação: 2012
  • Journal: Journal of Biotechnology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=A+new+cloning+system+based+on+the+OprI+lipoprotein+for+the+production+of+recombinant+bacterial+cell+wall-derived+immunogenic+formulations

The conjugation of antigens with ligands of pattern recognition receptors (PRR) is emerging as a promising strategy for the modulation of specific immunity. Here, we describe a new Escherichia coli system for the cloning and expression of heterologous antigens in fusion with the OprI lipoprotein, a TLR ligand from the Pseudomonas aeruginosa outer membrane (OM).
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Cell phenotypic change due to Cryptosporidium parvum infection in immunocompetent mice

  • Autores: Borrego M, Codices V, de Sousa B, Lopes A, Martins C, Matos O, Novo C, Pinho M
  • Ano de Publicação: 2013
  • Journal: Acta Parasitologica
  • Link: http://link.springer.com/article/10.2478%2Fs11686-013-0113-2

Cryptosporidium parvum is an intracellular parasite causing enteritis which can become life-threatening in immunocompromised host. Immunoregulatory T cells play a central role in the regulatory network of the host. Here, we proposed to characterize the populations of immune cells during infection and reinfection with C. parvum. Four-week-old BALB/C mice were inoculated with oocysts of C. parvum at days 0 and 22.
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Dynamics of cytokines and immunoglobulins serum profiles in primary and secondary Cryptosporidium parvum infection: Usefulness of Luminex® xMAP technology

  • Autores: Borrego M, Codices V, de Sousa B, Lopes T, Martins C, Matos O, Novo C
  • Ano de Publicação: 2013
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23178641

Infection by Cryptosporidium parvum triggers a complex array of innate and adaptive cell mediated immune response, playing an important role in controlling the infection. To date, there are no studies applying the Luminex® xMAP technology to determine profiles of cytokines and immunoglobulins in the context of an infection by C. parvum. In this study, we analyzed these immune mediators in the serum of immunocompetent mice inoculated with C. parvum oocysts, using Luminex, to understand how the immune system responds to an infection by this parasite.
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Canine leishmaniosis. Modulation of macrophage/lymphocyte interactions by L. infantum.

  • Autores: Alexandre-Pires G, Cartaxeiro C, da Fonseca IP, de Brito TV, Diaz S, Martins C, Rodrigues A, Santos-Gomes GM, Silva MJ
  • Ano de Publicação: 2012
  • Journal: Veterinary Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Canine+leishmaniosis.+Modulation+of+macrophage%2Flymphocyte+interactions+by+L.+infantum.

Canine leishmaniosis, caused by Leishmania infantum, is a systemic disease with variable clinical signs and a progressive evolution. This disease is characterized by impaired T cell-mediated immune response, which has been associated with disease chronicity and high mortality. Protective immunity against leishmaniosis is thought to be mediated by T cell and cytokine production.
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Canine leishmaniasis. Immunophenotypic profile of leukocytes in different compartments of symptomatic, asymptomatic and treated dogs

  • Autores: Alexandre-Pires G, Algueró C, da Fonseca IP, de Brito MT, Martins C, Rodrigues OR, Santos-Gomes G
  • Ano de Publicação: 2010
  • Journal: Veterinary immunology and immunopathology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Canine+leishmaniosis.+Immunophenotypic+profile+of+leukocytes+in+different+compartments+of+symptomatic%2C+asymptomatic+and+treated+dogs

Canine visceral leishmaniasis (CanL) is an emerging disease, expanding in various parts of the world. The infection caused by Leishmania, an intracellular protozoan parasite, can show different clinical manifestations, from asymptomatic or subclinical to symptomatic dogs, in which a wide spectrum of clinical signs is evident.
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New insights into neutrophil and Leishmania infantum in vitro immune interactions

  • Autores: Alexandre-Pires G, Correia I, Helena Ferronha M, Marques CS, Martins C, Passero LFD, Rodrigues A, Rodrigues OR, Santos-Gomes GM, Tomas AM, Vale-Gato I
  • Ano de Publicação: 2015
  • Journal: Comparative Immunology Microbiology and Infectious Diseases
  • Link: http://www.sciencedirect.com/science/article/pii/S0147957115000247

The interaction between polymorphonuclear leukocytes (PMN) or neutrophils and Leishmania became an interesting focus of research, since PMN turn out to be essential cells in transiently hosting the parasites.
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