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Instituto de Higiene e Medicina Tropical

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Decreasing population selection rates of resistance mutation K65R over time in HIV-1 patients receiving com- bination therapy including tenofovir

The use of tenofovir is highly associated with the emergence of mutation K65R, which confers broad resistance to nucleoside/nucleotide analogue reverse transcriptase inhibitors (NRTIs), especially when tenofovir is combined with other NRTIs also selecting for K65R. Although recent HIV-1 treatment guidelines discouraging these combinations resulted in reduced K65R selection with tenofovir, updated information on the impact of currently recommended regimens on the population selection rate of K65R is presently lacking.
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Physical fighting among school-going Portuguese adolescents: social and behavioural correlates.

OBJECTIVE:
The purpose of this study was to estimate the frequency and to assess the determinants of physical fighting among Portuguese school-going adolescents.
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Physical fighting among school-going Portuguese adolescents: social and behavioural correlates.

OBJECTIVE:
The purpose of this study was to estimate the frequency and to assess the determinants of physical fighting among Portuguese school-going adolescents.
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Does interview setting influence disclosure of violence? A study in elderly.

BACKGROUND:
Violence is a very sensitive research topic and interview’s setting might influence the participation rate and response accuracy. We aimed to evaluate such effect when assessing the prevalence of different types of violence in a sample of urban elderly by comparing those interviewed at home with those assessed at the research office.
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Does interview setting influence disclosure of violence? A study in elderly.

BACKGROUND:
Violence is a very sensitive research topic and interview’s setting might influence the participation rate and response accuracy. We aimed to evaluate such effect when assessing the prevalence of different types of violence in a sample of urban elderly by comparing those interviewed at home with those assessed at the research office.
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Mapping of mutations in the Plasmodium falciparum sarcoplasmic/endoplasmic reticulum Ca2+-atpase (pfATP6) gene in samples from equatorial guinea (Central Africa) unexposed to artemisinin-based combination therapy.

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Mapping of mutations in the Plasmodium falciparum sarcoplasmic/endoplasmic reticulum Ca2+-atpase (pfATP6) gene in samples from equatorial guinea (Central Africa) unexposed to artemisinin-based combination therapy.

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An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat gram-negative resistant bacteria.

The worldwide dissemination of «multi-drug resistant» (MDR) pathogens has severely reduced the efficacy of our antibiotic arsenal and increased the frequency of therapeutic failure. MDR bacteria over-express efflux pumps and this active mechanism can extrude all classes of antibiotics from the cell.
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