Canine leishmaniosis. Modulation of macrophage/lymphocyte interactions by L. infantum.
- Autores: Alexandre-Pires G, Cartaxeiro C, da Fonseca IP, de Brito TV, Diaz S, Martins C, Rodrigues A, Santos-Gomes GM, Silva MJ
- Ano de Publicação: 2012
- Journal: Veterinary Parasitology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Canine+leishmaniosis.+Modulation+of+macrophage%2Flymphocyte+interactions+by+L.+infantum.
Canine leishmaniosis, caused by Leishmania infantum, is a systemic disease with variable clinical signs and a progressive evolution. This disease is characterized by impaired T cell-mediated immune response, which has been associated with disease chronicity and high mortality. Protective immunity against leishmaniosis is thought to be mediated by T cell and cytokine production.