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Home / Archives for Alvarez C

Alvarez C

Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

  • Autores: Alvarez C, de Almeida Kruschewsky R, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, López G, Menezes SM, Moens B, Silva-Santos G, Talledo M, Van Weyenbergh J, Vandamme AM
  • Ano de Publicação: 2012
  • Journal: Plos Neglected Tropical Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Ascorbic+Acid+Has+Superior+Ex+Vivo+Antiproliferative%2C+Cell+Death-Inducing+and+Immunomodulatory+Effects+over+IFN-alpha+in+HTLV-1-Associated+Myelopathy

BACKGROUND:
Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) monotherapy in a large open clinical trial.
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Enhanced heterosexual transmission hypothesis for the origin of pandemic HIV-1.

  • Autores: Alvarez C, de Sousa JD, Müller V, Vandamme AM
  • Ano de Publicação: 2012
  • Journal: Viruses-Basel
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Enhanced+Heterosexual+Transmission+Hypothesis+for+the+Origin+of+Pandemic+HIV-1

HIV-1 M originated from SIVcpz endemic in chimpanzees from southeast Cameroon or neighboring areas, and it started to spread in the early 20th century. Here we examine the factors that may have contributed to simian-to-human transmission, local transmission between humans, and export to a city.
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CD80+ and CD86+ B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

  • Autores: Alvarez C, Brassat D, Decanine D, Galvão-Castro B, Gotuzzo E, Khouri R, Kruschewsky R, Liblau R, López G, Menezes SM, Schnitman SV, Talledo M, Vandamme AM, Weyenbergh JV
  • Ano de Publicação: 2014
  • Journal: Journal of Neuroinflammation
  • Link: http://www.jneuroinflammation.com/content/11/1/18

Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Currently, there are no disease-modifying therapies with long-term clinical benefits or validated biomarkers for clinical follow-up in HAM/TSP.
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