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Home / Archives for Viveiros M

Viveiros M

Why thioridazine in combination with antibiotics cures extensively drug-resistant Mycobacterium tuberculosis infections.

  • Autores: Amaral L, Viveiros M
  • Ano de Publicação: 2012
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/22445204

Thioridazine (TDZ) in combination with antibiotics to which extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) is initially resistant yields a cure. This is due to the fact that TDZ enhances the killing of intracellular M. tuberculosis by non-killing macrophages, inhibits the genetic expression of efflux pumps of M. tuberculosis that extrude antibiotics prior to reaching their intended targets, and inhibits the activity of existing efflux pumps that contribute to the multidrug-resistant phenotype of M. tuberculosis.
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Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB

  • Autores: Amaral L, Couto I, Dastidar S, Fanning S, Kristiansen JE, Martins A, Martins M, McCusker M, Molnar J, Pagès JM, Ramos J, Rodrigues L, Spengler G, Viveiros M
  • Ano de Publicação: 2010
  • Journal: In vivo
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Phenothiazines%2C+bacterial+efflux+pumps+and+targeting+the+macrophage+for+enhanced+killing+of+intracellular+XDRTB

Phenothiazines have their primary effects on the plasma membrane of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources, energy providing enzymes such as ATPases, and genes that regulate and code for permeability aspects of the bacterium.
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High-level resistance to isoniazid and ethionamide in multidrug-resistant Mycobacterium tuberculosis of the Lisboa family is associated with inhA double mutations

  • Autores: Boettger EC, Couto I, Machado D, Perdigão J, Portugal I, Ramos J, Ritter C, Viveiros M
  • Ano de Publicação: 2013
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23539241

The purpose of this study was to determine the levels of isoniazid and ethionamide resistance and to identify associated mutations in endemic multidrug-resistant (MDR) strains of Mycobacterium tuberculosis from the Lisbon metropolitan area, Portugal.
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Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus.

  • Autores: Amaral L, Costa SS, Couto I, Falcão C, Machado D, Martins M, Melo-Cristino J, Viveiros M
  • Ano de Publicação: 2011
  • Journal: BMC microbiology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Exploring+the+contribution+of+efflux+on+the+resistance+to+fluoroquinolones+in+clinical+isolates+of+Staphylococcus+aureus.

BACKGROUND:
Antimicrobial resistance mediated by efflux systems is still poorly characterized in Staphylococcus aureus, despite the description of several efflux pumps (EPs) for this bacterium. In this work we used several methodologies to characterize the efflux activity of 52 S. aureus isolates resistant to ciprofloxacin collected in a hospital in Lisbon, Portugal, in order to understand the role played by these systems in the resistance to fluoroquinolones.
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Activity of the efflux pump inhibitor SILA 421 against drug-resistant tuberculosis

  • Autores: Amaral L, Boeree MJ, Christensen JB, Hajos G, Kristiansen JE, Molnar J, Riedl Z, Simons SO, Van Der Laan T, Van Ingen J, Van Soolingen D, Viveiros M
  • Ano de Publicação: 2013
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23410790

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Competition between substrates of the efflux pump system of Salmonella enteritidis.

  • Autores: Amaral L, Cerca P, Couto I, Martins A, Viveiros M
  • Ano de Publicação: 2011
  • Journal: In vivo
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Competition+between+substrates+of+the+efflux+pump+system+of+Salmonella+enteritidis

AIM:
To determine whether tetracycline competes with ethidium bromide (EB), used as substrate of efflux pumps, for extrusion by the efflux pump system of Salmonella enteritidis NCTC 13349 reference strain.
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Description of plasmid pSM52, harbouring the gene for the Smr efflux pump, and its involvement in resistance to biocides in a meticillin-resistant Staphylococcus aureus strain

  • Autores: Amaral L, Costa SS, Couto I, Melo-Cristino J, Mourato C, Viveiros M
  • Ano de Publicação: 2013
  • Journal: International Journal of Antimicrobial Agents
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23434536

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Role of the mmr ef- flux pump in drug resistance in Mycobacterium tuberculosis

  • Autores: Ainsa JA, Bailo R, Rodrigues L, Villellas C, Viveiros M
  • Ano de Publicação: 2013
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23165464

Efflux pumps are membrane proteins capable of actively transporting a broad range of substrates from the cytoplasm to the exterior of the cell. Increased efflux activity in response to drug treatment may be the first step in the development of bacterial drug resistance.
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Enhanced Detection of Tuberculous Mycobacteria in Animal Tissues Using a Semi-Nested Probe-Based Real-Time PCR

  • Autores: Albuquerque T, Amaro A, Botelho A, Costa P, Couto I, Cunha MV, Ferreira AS, Inacio J, Viveiros M
  • Ano de Publicação: 2013
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081337

Bovine tuberculosis has been tackled for decades by costly eradication programs in most developed countries, involving the laboratory testing of tissue samples from allegedly infected animals for detection of Mycobacterium tuberculosis complex (MTC) members, namely Mycobacterium bovis. Definitive diagnosis is usually achieved by bacteriological culture, which may take up to 6–12 weeks, during which the suspect animal carcass and herd are under sanitary arrest.
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The activity of 16 new hydantoin compounds on the intrinsic and overexpressed efflux pump system of Staphylococcus aureus.

  • Autores: Amaral L, Armada A, Dymek A, Handzlik J, Kiec-Kononowicz K, Molnar J, Spengler G, Viveiros M
  • Ano de Publicação: 2012
  • Journal: In vivo
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Activity+of+16+New+Hydantoin+Compounds+on+the+Intrinsic+and+Overexpressed+Efflux+Pump+System+of+Staphylococcus+aureus

AIM:
To evaluate a new series of 16 hydantoin derivatives for activity against the intrinsic and overexpressed efflux pumps of the ATTC 25923 Staphylococcus aureus and the clinical Staphylococcus aureus HPV-107 strain, respectively.
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