Contribution of efflux activity to isoniazid resistance in the Mycobacterium tuberculosis complex.
- Autores: Amaral L, Couto I, Machado D, Rodrigues L, Viveiros M
- Ano de Publicação: 2012
- Journal: Genetics and Evolution
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Contribution+of+efflux+activity+to+isoniazid+resistance+in+the+Mycobacterium+tuberculosis+complex.+Infection
Resistance to isoniazid (INH), one of the main drugs used in tuberculosis (TB) therapy, is mostly due to chromosomal mutations in target genes. However, approximately 20-30% of INH resistant Mycobacterium tuberculosis isolates do not have mutations in any of the genes associated with INH resistance.