IHMT

Instituto de Higiene e Medicina Tropical

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An original deal for new molecule: reversal of efflux pump activity, a rational strategy to combat gram-negative resistant bacteria.

The worldwide dissemination of «multi-drug resistant» (MDR) pathogens has severely reduced the efficacy of our antibiotic arsenal and increased the frequency of therapeutic failure. MDR bacteria over-express efflux pumps and this active mechanism can extrude all classes of antibiotics from the cell.
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Evaluation of prevalence’s of pfdhfr and pfdhps mutations in Angola.

BACKGROUND:
Malaria is the major cause of morbidity and mortality in Angola. The most vulnerable groups to Plasmodium falciparum infection are pregnant women and children under five years of age.
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Evaluation of prevalence’s of pfdhfr and pfdhps mutations in Angola.

BACKGROUND:
Malaria is the major cause of morbidity and mortality in Angola. The most vulnerable groups to Plasmodium falciparum infection are pregnant women and children under five years of age.
Ler mais

Meta-evaluation of baseline studies of the Brazilian Family Health Strategy Expansion Project: a participatory and formative approach.

A participatory, formative meta-evaluation of baseline studies in Brazil is presented. International standards recommended by associations of evaluators were used, along with “specificity” criteria built up using the terms of reference for proposals for the selection of studies.
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Meta-evaluation of baseline studies of the Brazilian Family Health Strategy Expansion Project: a participatory and formative approach.

A participatory, formative meta-evaluation of baseline studies in Brazil is presented. International standards recommended by associations of evaluators were used, along with “specificity” criteria built up using the terms of reference for proposals for the selection of studies.
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Death from dengue fever as a sentinel event for evaluation of quality of healthcare: a case study in two municipalities in Northeast Brazil, 2008.

Despite the existing resources for adequate dengue patient care in the Brazilian healthcare system, the case-fatality rate for the disease is still high in the country.
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