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Home / Archives for Malaria Journal

Malaria Journal

Effectiveness of a new long-lasting insecticidal nets delivery model in two rural districts of Mozambique: a before–after study

  • Autores: Baltazar Candrinho, Chandana Mendis, João Pinto, Jorge A. H. Arroz, Maria do Rosário O Martins, Pablo Varela
  • Ano de Publicação: 2018
  • Journal: Malaria Journal
  • Link: https://link.springer.com/epdf/10.1186/s12936-018-2217-5?author_access_token=mbLKH79b1IvBS7R2VWfZzm_BpE1tBhCbnbw3BuzI2RNDKvB1mD1uBB_QQsbm9ICV5Tw9kPsIeSZ6diOXQ-J5PjOXVpHLrpbF20Vyk6-PZCaGbB5UvBddJLr0qPFdluxKP_bS2mHkYl8txPWwyl1Aww%3D%3D

In 2015, Mozambique piloted a new model of long-lasting insecticidal nets (LLINs) delivery in a
campaign. The new delivery model was used in two rural districts were, and two others were considered as control,
maintaining the old delivery model. The aim of this study is to compare the coverage of ownership and use of LLINs in intervention and control districts in Mozambique.
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In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

  • Autores: Bruce Russell, Carla Judice, Daniel Y. Bargieri, Fabio T. M. Costa, François Nosten, Irene S. Soares, Juliana A. Leite, Laurent Rénia, Letusa Albrecht, Marcelo U. Ferreira, Marcus V. G. Lacerda, Najara Bittencourt, Pedro Cravo, Renato B. Machado, Rossarin Suwanarusk, Stefanie C. P. Lopes, Taizy Leda, Yun Shan Goh
  • Ano de Publicação: 2018
  • Journal: Malaria Journal
  • Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2144-x

Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated.
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Implementation strategies to increase access and demand of long-lasting insecticidal nets: a before-and-after study and scale-up process in Mozambique

  • Autores: Baltazar Candrinho, Chandana Mendis, João Pinto, Jorge A. H. Arroz, Liliana Pinto, Maria do Rosário O Martins
  • Ano de Publicação: 2017
  • Journal: Malaria Journal
  • Link: https://malariajournal.biomedcentral.com/articles/10.1186/s12936-017-2086-3

The universal coverage bed nets campaign is a proven health intervention promoting increased access, ownership, and use of bed nets to reduce malaria burden. This article describes the intervention and implementation strategies that Mozambique carried out recently in order to improve access and increase demand for long-lasting insecticidal nets (LLINs).
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Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria

  • Autores: Costa RM, De Sousa KP, Nogueira F, Silva MS, Vitorino R
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/100

The malaria caused by Plasmodium falciparum remains a serious public health problem in the world, due largely to the absence of an effective vaccine. There is a lack of information on the structural properties and antigens capable of activating the immunological mechanisms for the induction of protective immunity. Therefore, the objective of this study is to evaluate the serological reactivity of sera from individuals with imported malaria and identify major immunogenic proteins.
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. In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy

  • Autores: de Sousa B, Fernandes N, Figueiredo P, Lobo E, Lobo L, Nogueira F, Pateira S, Rosa S
  • Ano de Publicação: 2014
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/13/1/300

Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 different alleles in Maputo and Mozambique is not known, either after or before the introduction of ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed before and after transition to ACT.
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Genetic diversity and signatures of selection of drug resistance in Plasmodium populations from both human and mosquito hosts in continental Equatorial Guinea

  • Autores: Arez AP, Benito A, Berzosa P, Cano J, de Sousa B, Do Rosário VE, Gonzalez V, Mendes C, Salgueiro P
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/114

In Plasmodium, the high level of genetic diversity and the interactions established by co-infecting parasite populations within the same host may be a source of selection on pathogen virulence and drug resistance. As different patterns have already been described in humans and mosquitoes, parasite diversity and population structure should be studied in both hosts to properly assess their effects on infection and transmission dynamics. This study aimed to characterize the circulating populations of Plasmodium spp and Plasmodium falciparum from a combined set of human blood and mosquito samples gathered in mainland Equatorial Guinea. Further, the origin and evolution of anti-malarial resistance in this area, where malaria remains a major public health problem were traced.
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Immunoproteomic analysis of Plasmodium falciparum antigens using sera from patients with clinical history of imported malaria

  • Autores: Costa RM, De Sousa KP, Nogueira F, Silva MS, Vitorino R
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/100

Background The malaria caused by Plasmodium falciparum remains a serious public health problem in the world, due largely to the absence of an effective vaccine. There is a lack of information on the structural properties and antigens capable of activating the immunological mechanisms for the induction of protective immunity. Therefore, the objective of this study […]
Ler mais

In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
Ler mais

Genetic and phenotypic variation of the malaria vector Anopheles atroparvus in southern Europe.

  • Autores: Alten B, Alves R, Bargues MD, Barré H, Boccolini D, Caglar SS, Demirci B, Di Luca M, Do Rosário VE, Falcutá E, Fontenille D, Latorre JM, Mas-Coma S, Nicolescu G, Ozer N, Pinto J, Romi R, Salgueiro P, Silva TL, Sousa CA, Toma L, Toty C, Vicente JL
  • Ano de Publicação: 2011
  • Journal: Malaria Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Genetic+and+phenotypic+variation+of+the+malaria+vector+Anopheles+atroparvus+in+southern+Europe

BACKGROUND:
There is a growing concern that global climate change will affect the potential for pathogen transmission by insect species that are vectors of human diseases. One of these species is the former European malaria vector, Anopheles atroparvus. Levels of population differentiation of An. atroparvus from southern Europe were characterized as a first attempt to elucidate patterns of population structure of this former malaria vector.
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