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Home / Archives for Brasil LW

Brasil LW

. In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
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Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Costa MR, Lacerda MV, Marques MM, Monteiro WM, Nascimento MT, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JL
  • Ano de Publicação: 2014
  • Journal: Antimicrob Agents Chemother
  • Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12

In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue.
Ler mais

In vitro chloroquine resistance for Plasmodium vivax isolates from the Western Brazilian Amazon

  • Autores: Alecrim MG, Brasil LW, Chehuan YF, Costa JS, Costa MR, Lacerda MV, Melo GC, Monteiro WM, Nogueira F, Silveira H
  • Ano de Publicação: 2013
  • Journal: Malaria Journal
  • Link: http://www.malariajournal.com/content/12/1/226

Chloroquine (CQ) and primaquine (PQ) are still the drugs of choice to treat Plasmodium vivax malaria in many endemic areas, Brazil included. There is in vivo evidence for the P. vivax resistance to CQ in the Brazilian Amazon, where the increase in the proportion of P. vivax malaria parallels the increase of unusual clinical complications related to this species. In this study, in vitro CQ and mefloquine (MQ)-susceptibility of P. vivax isolates from the Western Brazilian Amazon was tested using the double-site enzyme-linked lactate dehydrogenase immunodetection (DELI) assay.
Ler mais

Plasmodium vivax Chloroquine Resistance and Anemia in the Western Brazilian Amazon

  • Autores: Alecrim MGC, Brasil LW, Costa MRF, Lacerda MVG, Marques MM, Monteiro WM, Nascimento MTS, Nogueira F, Reyes-Lecca RC, Santana Filho FS, Silveira H, Vieira JLF
  • Ano de Publicação: 2014
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: http://aac.asm.org/content/early/2013/10/22/AAC.02279-12

In Latin America, data on chloroquine (CQ)-resistant Plasmodium vivax is limited, even with the current research efforts to sustain an efficient malaria control program in all these endemic countries, where malaria still is a major public health issue. This study estimated in vivo CQ-resistance in uncomplicated patients with P. vivax in use of CQ and primaquine simultaneously, in the Brazilian Amazon. From a total of 135 enrolled subjects, who accomplished the 28-day follow-up, parasitological failure was observed in 7 (5.2%) patients, in which plasmatic CQ and desethylchloroquine (DCQ) concentrations were above 100ng/dL.
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