Identification of papain-like cysteine proteases from the bovine piroplasm Babesia bigemina and evolutionary relationship of piroplasms C1 family of cysteine proteases.
- Autores: Do Rosário VE, Domingos A, Martins TM
- Ano de Publicação: 2011
- Journal: Experimental Parasitology
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+papain-like+cysteine+proteases+from+the+bovine+piroplasm+Babesia+bigemina+and+evolutionary+relationship+of+piroplasms+C1+family+of+cysteine+proteases.
Papain-like cysteine proteases have been shown to have essential roles in parasitic protozoa and are under study as promising drug targets. Five genes were identified by sequence similarity search to be homologous to the cysteine protease family in the ongoing Babesia bigemina genome sequencing project database and were compared with the annotated genes from the complete bovine piroplasm genomes of Babesia bovis, Theileria annulata, and Theileria parva.