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Instituto de Higiene e Medicina Tropical

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2018

Evolution of the Medical Education Policy in Cabo Verde

Cabo Verde é um dos Pequenos Estados Insulares em Desenvolvimento do mundo, com especificidades e desafios próprios. Independente há 43 anos, com meio milhão de habitantes, a formação dos seus médicos tem sido feita no exterior, incrementando a força de trabalho do país, mas não o suficiente, em número e diferenciação, para sustentar os desafios da saúde, nomeadamente a extensão da cobertura universal. Em 2015 as autoridades decidiram implantar a educação médica local, tornando necessário reformular a Política de Educação Médica enquanto política de educação e de saúde, envolvendo os vários atores, organizações e instituições.
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Elucidating in vitro and in vivo phenotypic behaviour of L. infantum/L. major natural hybrids

The clinical manifestation and course of Leishmania infections depend on factors such as species, virulence and host-immunity. Although trypanosomatids are considered to have clonal propagation, genetic hybridization has produced successful natural hybrid lineages. Hybrids displaying strong selective advantages may have an impact on pathogenesis and the ecoepidemiology of leishmaniasis. Thus, characterization of phenotypic properties of Leishmania hybrids could bring significant insight into the biology, infectivity, pathogenicity and transmission dynamics of these atypical strains.
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Effectiveness of a new long-lasting insecticidal nets delivery model in two rural districts of Mozambique: a before–after study

In 2015, Mozambique piloted a new model of long-lasting insecticidal nets (LLINs) delivery in a
campaign. The new delivery model was used in two rural districts were, and two others were considered as control,
maintaining the old delivery model. The aim of this study is to compare the coverage of ownership and use of LLINs in intervention and control districts in Mozambique.
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Mosquito-borne arboviruses of African origin: review of key viruses and vectors

Key aspects of 36 mosquito-borne arboviruses indigenous to Africa are summarized, including lesser or poorly-known viruses which, like Zika, may have the potential to escape current sylvatic cycling to achieve greater geographical distribution and medical importance. Major vectors are indicated as well as reservoir hosts, where known. A series of current and future risk factors is addressed.
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In silico epitope mapping and experimental evaluation of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) as a malaria vaccine candidate

Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated.
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