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Home / Publicações

Citizen science initiative points at childhood BCG vaccination as a risk factor for COVID‐19

  • Autores: José de la Fuente, Octavio Armas, Luis Sánchez‐Rodríguez, Christian Gortázar, Alexander N. Lukashev, COVID‐BCG Collaborative Working Group
  • Ano de Publicação: 2021
  • Journal: Wiley Online Library
  • Link: https://onlinelibrary.wiley.com/doi/epdf/10.1111/tbed.14097

Abstract Current results do not provide conclusive evidence on the effect of BCG vaccination on COVID‐19 alone or in combination with other factors. To address this limitation, in this study we used a citizen science initiative on the COVID‐19 pandemic to collect data worldwide during October 2‐30, 2020 (1,233 individuals) in a structured way for […]
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Comparative analysis of Rhipicephalus tick salivary gland and cement elementome

  • Autores: Iván Pacheco, Eduardo Prado, Sara Artigas-Jerónimo, José Francisco Lima-Barbero, Gabriela de la Fuente, Sandra Antunes, Joana Couto, Ana Domingos, Margarita Villar, José de la Fuente
  • Ano de Publicação: 2021
  • Journal: Heliyon
  • Link: https://www.sciencedirect.com/science/article/pii/S2405844021008240?via%3Dihub%20

Abstract Rhipicephalus spp. (Acari: Ixodidae) ticks are obligate hematophagous arthropods, which constitute a model for the study of vector-host interactions. The chemical composition or elementome of salivary glands (SG) and cement provides information relevant for the study of protein-based complex multifunctional tissues with a key role in tick biology. In this study, we characterized the elementome of […]
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Probing the Rhipicephalusbursa Sialomes in Potential Anti-Tick Vaccine Candidates: A Reverse Vaccinology Approach

  • Autores: Joana Couto, Gonçalo Seixas, Christian Stutzer, Nicholas A Olivier, Christine Maritz-Olivier, Sandra Antunes, Ana Domingos
  • Ano de Publicação: 2021
  • Journal: PubMed

Abstract In the wake of the ‘omics’ explosion of data, reverse vaccinology approaches are being applied more readily as an alternative for the discovery of candidates for next generation diagnostics and vaccines. Promising protective antigens for the control of ticks and tick-borne diseases can be discovered by mining available omics data for immunogenic epitopes. The […]
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Characterization of the Rhipicephalus (Boophilus) microplus Sialotranscriptome Profile in Response to Theileria equi Infection

  • Autores: Patrícia Paulino, Gabriela Vitari, Antonio Rezende, Joana Couto, Sandra Antunes, Ana Domingos, Maristela Peckle, Carlos Massard, Flávio Araújo, Huarrisson Santos
  • Ano de Publicação: 2021
  • Journal: Mdpi
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913801/

Abstract This study intends to characterize the sialotranscriptome profile of Rhipicephalus (Boophilus) microplus in response to Theileria equi and identify genes of interest with differential genomic expression, indicating relevant targets in the tick–protozoan interactions. The experimental design consisted of RNA sequencing from uninfected and T. equi-infected R. microplus salivary glands (SGs) to obtain transcriptomic profiles for characterization and comparison. A total of […]
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Comparative Proteomic Analysis of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) Tropical and Temperate Lineages: Uncovering Differences During Ehrlichia canis Infection

  • Autores: Gustavo Seron Sanches, Margarita Villar, Joana Couto, Joana Ferrolho, Isabel G. Fernández de Mera, Marcos Rogério André, Darci Moraes Barros-Battesti, Rosangela Zacarias Machado, Gervásio Henrique Bechara, Lourdes Mateos-Hernández, José de la Fuente, Sandra Antunes, Ana Domingos
  • Ano de Publicação: 2021
  • Journal: Frontiers in Cellular and Infection Microbiology
  • Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7879575/

Abstract The tick vector Rhipicephalus sanguineus is established as a complex of closely related species with high veterinary-medical significance, in which the presence of different genetic, morphological, and biological traits has resulted in the recognition of different lineages within taxa. One of the most striking differences in the “temperate” and “tropical” lineages of R. sanguineus (s.l.) is the vector […]
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Health Problems During and After Travel: A Prospective Observational Study in a Travel Clinic in Portugal

  • Autores: Cláudia Conceição, Márcia Medeiros, Nélia Pereira, Luzia Gonçalves, Abilio Antunes, Ellen Blondé, Rosa Teodósio, Carlos Araújo, Filomena Pereira
  • Ano de Publicação: 2021
  • Journal: Acta Mérdica Portuguesa

Abstract Introduction: In order to improve the health of travellers during travel it is important to better understand the health problems faced by travellers in different destinations. The main objective of this study was to characterise the perceived health problems of travellers during and up to six months after travel on a pre-travel clinic in Lisbon, […]
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Telemedicine to deliver diabetes care in low- and middle-income countries: a systematic review and meta-analysis

  • Autores: Jorge César Correia, Hafsa Meraj, Soo Huat Teoh, Ahmed Waqas, Maaz Ahmad, Luís Velez Lapão, Zoltan Patakya & Alain Golay
  • Ano de Publicação: 2021
  • Journal: Bulletin of the World Health Organization

Diabetes mellitus is one of the most prevalent chronic and preventable conditions affecting over 415 million people globally, and accounted for over 5 million deaths in 2015. Because the symptoms of diabetes affect both the micro- and macrovascular systems, the disease is associated with significant morbidity, mortality and a poor quality of life. By 2030, […]
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The SARS-CoV-2 pandemic: A syndemic perspective

  • Autores: Inês Fronteira, Mohsin Sidat, João Paulo Magalhães, Fernando Passos Cupertino de Barros, Antonio Pedro Delgado, Tiago Correia, Cláudio Tadeu Daniel-Ribeiro, Paulo Ferrinho
  • Ano de Publicação: 2021
  • Journal: Elsevier

Abstract The SARS-CoV-2 pandemic has affected communities, populations, and countries throughout the world. As the SARS-CoV-2 pandemic developed, the extent to which the disease interacted with already existing endemic, non-communicable and infectious diseases became evident, hence deeply influencing health outcomes. Additionally, a synergistic effect has been demonstrated also with socio-economic, cultural, and contextual determinants of […]
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Comparative Proteomic Analysis of Rhipicephalus sanguineus sensu lato (Acari: Ixodidae) Tropical and Temperate Lineages: Uncovering Differences During Ehrlichia canis Infection

  • Autores: Gustavo Seron Sanches1, Margarita Villar, Joana Couto, Joana Ferrolho, Isabel G. Fernández de Mera, Marcos Rogério André, Darci Moraes Barros-Battesti, Rosangela Zacarias Machado, Gervásio Henrique Bechara, Lourdes Mateos-Hernández, José de la Fuente, Sandra Antunes, Ana Domingos
  • Ano de Publicação: 2021
  • Journal: Frontiers in Cellular and Infection Microbiology

The tick vector Rhipicephalus sanguineus is established as a complex of closely related species with high veterinary-medical significance, in which the presence of different genetic, morphological, and biological traits has resulted in the recognition of different lineages within taxa. One of the most striking differences in the “temperate” and “tropical” lineages of R. sanguineus (s.l.) is the vector competence […]
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Migration as a Determinant in the Development of Children Emotional and Behavior Problems: A Quantitative Study for Lisbon Region, Portugal

  • Autores: Zelia Muggli, Thierry Mertens, Silva -Sá, Regina Amado, Ana L. Teixeira, Dora Vaz, Maria Rosario O. Martins
  • Ano de Publicação: 2021
  • Journal: International Journal of Environmental Research and Public Health
  • Link: https://www.mdpi.com/1660-4601/18/2/375/pdf

Abstract: The role of migration as a determinant in child mental health has been demonstrated in a number of studies. However, results are not always consistent, and the research continues to be scarce, especially in Portugal. We examined the association between sociodemographic profiles and the chance for the development of emotional and behavioral difficulties in […]
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