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Instituto de Higiene e Medicina Tropical

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COVID-19 treatment in sub-Saharan Africa: If the best is not available, the available becomes the best

Community transmission of COVID-19 is ongoing in the majority of countries in sub-Saharan Africa (SSA), threatening, as elsewhere, the capacity of national healthcare systems (HCS) in low- and middle-income countries (LMIC) [1, 2]. While the epidemic started slowly and late in SSA, currently – subject to often rapid changes – around 20,000 cases per day […]
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The case for simplifying and using absolute targets for viral hepatitis elimination goals

Abstract The 69th World Health Assembly endorsed the Global Health Sector Strategy for Viral Hepatitis, embracing a goal to eliminate hepatitis infection as a public health threat by 2030. This was followed by the World Health Organization’s (WHO) global targets for the care and management of hepatitis B virus (HBV) and hepatitis C virus (HCV) […]
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Harnessing Telemedicine for the Provision of Health Care: Bibliometric and Scientometric Analysis

ABSTRACT Background: In recent decades, advances in information technology have given new momentum to telemedicine research. These advances in telemedicine range from individual to population levels, allowing the exchange of patient information for diagnosis and management of health problems, primary care prevention, and education of physicians via distance learning. Objective: This scientometric investigation aims to examine collaborative […]
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The Writing’s on the Wall: On Health Inequalities, Migrants, and Coronavirus

Migrants and ethnic minorities who lack access to health services and information are particularly vulnerable to the impact of COVID-19. In this opinion, we aimed to explain how these challenges can affect the spread of COVID-19 in the European Union and the United Kingdom, and to stress the importance of universal and equitable access to […]
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Common Medical and Statistical Problems: The Dilemma of the Sample Size Calculation for Sensitivity and Specificity Estimation

Abstract Sample size calculation in biomedical practice is typically based on the problematic Wald method for a binomial proportion, with potentially dangerous consequences. This work highlights the need of incorporating the concept of conditional probability in sample size determination to avoid reduced sample sizes that lead to inadequate confidence intervals. Therefore, new definitions are proposed […]
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COVID-19: What Is Next for Portugal?

Highly infectious with the possibility of causing severe respiratory complications, the novel COVID-19 began stretching health systems beyond their capacity all over the world and pushing them to breaking points. Giving the devastating effects caused by this infection, unprecedented measures have to be adopted in order to mitigate its impacts on the health system. This […]
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Social determinants of deaths from pneumonia and tuberculosis in children in Brazil: an ecological study

Abstract Objective To identify the risk areas of deaths due to unspecified pneumonia and tuberculosis (TB) in children, and to identify if there is a relationship between these events with higher TB incidence and social determinants. Methods Ecological study carried out in Brazil. All cases of TB or unspecified pneumonia deaths in children under 5 years of […]
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Principalism in public health decision making in the context of the COVID ‐19 pandemic

This research is among top 10 most downloaded papers. Background The COVID‐19 pandemic lead scientists and governmental authorities to issue clinical and public health recommendations based on progressively emerging evidence and expert opinions and many of these fast‐tracked to peer‐reviewed publications. Concerns were raised on scientific quality and generalizability of this emerging evidence. Main argument […]
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Hepatitis delta virus interacts with splicing factor SF3B155 and alters pre‐mRNA splicing of cell cycle control genes

Hepatitis delta virus (HDV) is the agent responsible for the most severe form of human viral hepatitis. The HDV genome consists of a single‐stranded circular RNA molecule that encodes for one single protein, the delta antigen. Given its simplicity, HDV must make use of several host cellular proteins to accomplish its life cycle processes, including […]
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Epidemic and Pandemic Viral Infections: Impact on Tuberculosis and the Lung. A Consensus by the World Association for Infectious Diseases and Immunological Disorders (WAidid), Global Tuberculosis Network (GTN) and Members # of ESCMID Study Group for Mycobacterial Infections (ESGMYC)

Major epidemics including some that qualify as pandemics, such as Severe Acute Respiratory Syndrome (SARS), Middle-Eastern Respiratory Syndrome (MERS), Human Immunodeficiency Virus, pandemic H1N1/09 and most recently COVID-19 affect the lung. Tuberculosis (TB) remains the top infectious disease killer but apart from the TB-HIV syndemic, little is known regarding the interaction of viral epidemics and […]
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