Is prnt a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa.
- Autores: Baptista MC, Barbas JP, Cantante C, Domingos A, Fontes CA, Gonçalves J, Horta AE, Marques CC, Mesquita P, Pereira RM, Pimenta J, Prates JA, Santos A, Santos P, Viegas A
- Ano de Publicação: 2012
- Journal: PLoS One
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Is+prnt+a+Pseudogene%3F+Identification+of+Ram+Prt+in+Testis+and+Ejaculated+Spermatozoa.
A hallmark of prion diseases or transmissible spongiform encephalopaties is the conversion of the cellular prion protein (PrP(C)), expressed by the prion gene (prnp), into an abnormally folded isoform (PrP(Sc)) with amyloid-like features that causes scrapie in sheep among other diseases. prnp together with prnd (which encodes a prion-like protein designated as Doppel), and prnt (that encodes the prion protein testis specific–Prt) with sprn (shadow of prion protein gene, that encodes Shadoo or Sho) genes, constitute the “prion gene complex”.