Why and how thioridazine in combination with antibiotics to which the infective strain is resistant will cure totally drug-resistant tuberculosis.
- Autores: Amaral L, Molnar J
- Ano de Publicação: 2012
- Journal: Expert Review of Anti-infective Therapy
- Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Why+and+How+Thioridazine+in+combination+with+antibiotics+to+which+the+infective+strain+is+resistant+will+cure+totally+drug+resistant+tuberculosis+(TDR+TB)
Over a period of 14 years, the authors have studied thioridazine, an old neuroleptic, that has been shown to have in vitro activity against intracellular Mycobacterium tuberculosis, regardless of its antibiotic resistance status, thioridazine cures infected mice of antibiotic-susceptible and multidrug-resistant tuberculosis (TB) infections and, when used in combination with antibiotics used for therapy of TB, renders the organism significantly more susceptible.