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Home / Archives for Pinto J

Pinto J

Pyruvate kinase deficiency in sub-Saharan Africa: identification of a highly frequent missense mutation (G829A;Glu277Lys) and association with malaria.

  • Autores: Amorim A, Arez AP, Cano J, Chibute S, Do Rosário VE, Fernandes N, Gomes C, Langa J, Machado P, Manco L, Mendes C, Miranda J, Pinto J, Ribeiro L, Salomé G, Sitoe L
  • Ano de Publicação: 2012
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Pyruvate+Kinase+Deficiency+in+Sub-Saharan+Africa%3A+Identification+of+a+Highly+Frequent+Missense+Mutation+(G829A%3B+Glu277Lys)+and+Association+with+Malaria

BACKGROUND:
Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as well as finding a prevalent PK variant underlying this deficiency.
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Genetic isolation within the malaria mosquito Anopheles melas.

  • Autores: Athrey G, Caccone A, Costantini C, Deitz KC, Della Torre A, Jawara M, Kengne P, Kiszewski AE, Matias A, Overgaard HJ, Petrarca V, Pinto J, Reddy MR, Slotman MA
  • Ano de Publicação: 2012
  • Journal: Molecular Ecology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/22882458

Anopheles melas is a brackish water-breeding member of the Anopheles gambiae complex that is distributed along the coast of West Africa and is a major malaria vector within its range. Because little is known about the population structure of this species, we analysed 15 microsatellite markers and 1161 bp of mtDNA in 11 A.
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Gene flow-dependent genomic divergence between Anopheles gambiae M and S forms.

  • Autores: Donnelly MJ, Pinto J, Steen K, Weetman D, Wilding CS
  • Ano de Publicação: 2012
  • Journal: Molecular Biology and Evolution
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Gene+Flow-Dependent+Genomic+Divergence+between+Anopheles+gambiae+M+and+S+Forms.

Anopheles gambiae sensu stricto exists as two often-sympatric races termed the M and S molecular forms, characterized by fixed differences at an X-linked marker. Extreme divergence between M and S forms at pericentromeric “genomic islands” suggested that selection on variants therein could be driving interform divergence in the presence of ongoing gene flow, but recent work has detected much more widespread genomic differentiation.
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The Culex pipiens complex in continental Portugal: distribution and genetic structure.

  • Autores: Almeida AP, Donnelly MJ, Gomes B, Novo MT, Parreira R, Pinto J, Sousa CA
  • Ano de Publicação: 2012
  • Journal: Journal of the American Mosquito Control Association
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+Culex+pipiens+complex+in+continental+Portugal%3A+Distribution+and+genetic+structure.

Portugal is a southern European country that displays favorable ecological conditions for the establishment of West Nile virus (WNV) transmission cycles. Competent mosquito vector species are present throughout the country.
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Geographic structuring of the Plasmodium falciparum sarco(endo)plasmic reticulum Ca2+ ATPase (PfSERCA) gene diversity

  • Autores: Alecrim Md, Benito A, Berzosa P, Bouchier C, Cravo P, Ekala MT, Fandeur T, Ferreira C, Ferreira ID, Gribaldo S, Jambou R, Kim N, Legrand E, Martinelli A, Mercereau-Puijalon O, Niang M, Pharath L, Pinto J, Vieira PP, Volnay B
  • Ano de Publicação: 2010
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Geographic+structuring+of+the+Plasmodium+falciparum+Sarco(endo)plasmic+reticulum+Ca2%2B+ATPase+(PfSERCA)+gene+diversity

Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant parasites, we conducted a sequence analysis of 100 isolates from multiple sites in Africa, Asia and South America. Coding sequence diversity was […]
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Studies on the behaviour of peridomestic and endophagic M form Anopheles gambiae from a rice growing area of Ghana.

  • Autores: Charlwood JD, Egyir-Yawson A, Pinto J, Pitts RJ, Salgueiro P, Tomás EV
  • Ano de Publicação: 2011
  • Journal: Bulletin of entomological research
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Studies+on+the+behaviour+of+peridomestic+and+endophagic+M+form+Anopheles+gambiae+from+a+rice+growing+area+of+Ghana

The ‘paddy paradox’, the occurrence of large populations of vectors but low amounts of malaria transmission where irrigated rice is grown, was investigated in a village in Ghana where M form Anopheles gambiae are common.
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Aedes aegypti on Madeira Island (Portugal): genetic variation of a recently introduced dengue vector. Memórias do Instituto Oswaldo Cruz

  • Autores: Campos M, Novo MT, Pinto J, Reyes-Lugo M, Ribolla PEM, Salgueiro P, Seixas G, Silva AC, Sousa CA, Spenassatto C
  • Ano de Publicação: 2013
  • Journal: Memorias do Instituto Oswaldo Cruz
  • Link: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000900003

The increasing population of Aedes aegypti mosquitoes on Madeira Island (Portugal) resulted in the first autochthonous dengue outbreak, which occurred in October 2012. Our study establishes the first genetic evaluation based on the mitochondrial DNA (mtDNA) genes [cytochrome oxidase subunit I (COI) and NADH dehydrogenase subunit 4 (ND4)] and knockdown resistance ( kdr ) mutations exploring the colonisation history and the genetic diversity of this insular vector population.
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New Insights into the Population Structure of Anopheles gambiae s.s. in the Gulf of Guinea Islands Revealed by Herves Transposable Elements

  • Autores: Moreno M, O’Brochta D, Pinto J, Salgueiro P, Simard F
  • Ano de Publicação: 2013
  • Journal: PLoS One
  • Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0062964

Transposable elements (TEs) are mobile portions of DNA that are able to replicate and spread in the genome of many organisms. TEs can be used as a means to insert transgenes in insects, being stably inherited throughout generations.
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The “far-west” of Anopheles gambiae molecular forms.

  • Autores: Besansky NJ, Caputo B, Conway DJ, Della Torre A, Jaenson T, Jawara M, Mancini E, Nwakanma DC, Palsson K, Petrarca V, Pinto J, Santolamazza F, Vicente JL, White BJ
  • Ano de Publicação: 2011
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+%E2%80%9Cfar-west%E2%80%9D+of+Anopheles+gambiae+molecular+forms

The main Afrotropical malaria vector, Anopheles gambiae sensu stricto, is undergoing a process of sympatric ecological diversification leading to at least two incipient species (the M and S molecular forms) showing heterogeneous levels of divergence across the genome.
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Field, genetic, and modeling approaches show strong positive selection acting upon an insecticide resistance mutation in Anopheles gambiae s.s

  • Autores: Barbosa S, Donnelly MJ, Egyir-Yawson A, Hastings I, Lynd A, Mitchell S, Pinto J, Weetman D
  • Ano de Publicação: 2010
  • Journal: Molecular Biology and Evolution
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Field%2C+genetic+and+modeling+approaches+show+strong+positive+selection+acting+upon+an+insecticide+resistance+mutation+in+Anopheles+gambiae+s.s

Alleles subject to strong, recent positive selection will be swept toward fixation together with contiguous sections of the genome. Whether the genomic signatures of such selection will be readily detectable in outbred wild populations is unclear. In this study, we employ haplotype diversity analysis to examine evidence for selective sweeps around knockdown resistance (kdr) mutations […]
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