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Home / Archives for Clinical microbiology and infection

Clinical microbiology and infection

Multicentre testing of the EUCAST broth microdilution reference method for MIC determination on Mycobacterium tuberculosis

  • Autores: Thomas Schön, Jim Werngren, Diana Machado, Emanuele Borroni, Maria Wijkander, Gerard Lina, Johan Mouton, Erika Matuschek, Gunnar Kahlmeter, Christian Giske, Miguel Santin, Daniela Maria Cirillo, Miguel Viveiros, Emmanuelle Cambau
  • Ano de Publicação: 2020
  • Journal: Clinical microbiology and infection
  • Link: https://www.sciencedirect.com/science/article/pii/S1198743X20306509

Abstract Objectives: The first objective of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) subcommittee for antimycobacterial susceptibility testing (AMST), launched in 2016, was to set a reference method for determining the MICs of antituberculous agents, since many protocols are used worldwide and a consensus one is needed for the determination of microbiological breakpoints. Methods: […]
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Diagnosis of Pneumocystis pneumonia: evaluation of four serologic biomarkers

  • Autores: Antunes F, Badura R, CALDERÓN E. J., CALÉ S. S., DE BOER M. G., Esteves F, Maltez F, MARQUEZ-MARTIN E., Matos O, VAN DER REIJDEN T. J.
  • Ano de Publicação: 2015
  • Journal: Clinical microbiology and infection
  • Link: http://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)00111-6/abstract

This study aimed to assess the usefulness of (1–3)-β-d-glucan (BG), Krebs von den Lungen-6 antigen (KL-6), lactate dehydrogenase (LDH) and S-adenosyl methionine (SAM) as serologic biomarkers in the diagnosis of PCP.
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Multicentre study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia

  • Autores: Antunes F, Badura R, BASSAT Q., CALDERÓN E. J., de Armas Y, de Sousa B, Esteves F, HUANG L., Maltez F, Matos O
  • Ano de Publicação: 2016
  • Journal: Clinical microbiology and infection
  • Link: https://www.ncbi.nlm.nih.gov/pubmed/27021425

Pneumocystis jirovecii causes severe interstitial pneumonia (PcP) in immunosuppressed patients. This multicentre study assessed the distribution frequencies of epidemiologically relevant genetic markers of P. jirovecii in different geographic populations from Portugal, the USA, Spain, Cuba and Mozambique, and the relationship between the molecular data and the geographical and clinical information, based on a multifactorial approach.
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Pneumocystis jirovecii multilocus genotyping in pooled DNA samples: a new approach for clinical and epidemiological studies.

  • Autores: Antunes F, de Sousa B, Esteves F, Gaspar J, Mansinho K, Matos O
  • Ano de Publicação: 2012
  • Journal: Clinical microbiology and infection
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Pneumocystis+jirovecii+multilocus+genotyping+in+pooled+DNA+samples%3A+a+new+approach+for+clinical+and+epidemiological+studies.

Specific single-nucleotide polymorphisms (SNPs) are recognized as important DNA sequence variations influencing the pathogenesis of Pneumocystis jirovecii and the clinical outcome of Pneumocystis pneumonia, which is a major worldwide cause of illness among immunocompromised patients
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Identification of relevant single-nucleotide polymorphisms in Pneumocystis jirovecii: relationship with clinical data

  • Autores: Antunes F, Esteves F, Gaspar J, Leite R, Mansinho K, Marques T, Matos O
  • Ano de Publicação: 2010
  • Journal: Clinical microbiology and infection
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Identification+of+relevant+Single+Nucleotide+Polymorphisms+in+Pneumocystis+jirovecii%3A+relationship+with+clinical+data

Pneumocystis jirovecii is a poorly understood pathogen that causes opportunistic pneumonia (Pneumocystis pneumonia (PcP)) in patients with AIDS.
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Predicted residual activity of rilpivirine in HIV-1 infected patients failing therapy including NNRTIs efavirenz or nevirapine

  • Autores: Camacho RJ, Gomes P, Portuguese HIVRSG, Rhee SY, Theys K, Vandamme AM
  • Ano de Publicação: 2015
  • Journal: Clinical microbiology and infection
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25704446

Rilpivirine is a second-generation nonnucleoside reverse-transcriptase inhibitor (NNRTI) currently indicated for first-line therapy, but its clinical benefit for HIV-1 infected patients failing first-generation NNRTIs is largely undefined.This study quantified the extent of genotypic rilpivirine resistance in viral isolates from 1212 patients upon failure of efavirenz- or nevirapine-containing antiretroviral treatment, of whom more than respectively 80% and 90% showed high-level genotypic resistance to the failing NNRTI.
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