Instituto de Higiene e Medicina Tropical
Migrants and ethnic minorities who lack access to health services and information are particularly vulnerable to the impact of COVID-19. In this opinion, we aimed to explain how these challenges can affect the spread of COVID-19 in the European Union and the United Kingdom, and to stress the importance of universal and equitable access to […]
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Abstract Sample size calculation in biomedical practice is typically based on the problematic Wald method for a binomial proportion, with potentially dangerous consequences. This work highlights the need of incorporating the concept of conditional probability in sample size determination to avoid reduced sample sizes that lead to inadequate confidence intervals. Therefore, new definitions are proposed […]
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Highly infectious with the possibility of causing severe respiratory complications, the novel COVID-19 began stretching health systems beyond their capacity all over the world and pushing them to breaking points. Giving the devastating effects caused by this infection, unprecedented measures have to be adopted in order to mitigate its impacts on the health system. This […]
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Abstract Objective To identify the risk areas of deaths due to unspecified pneumonia and tuberculosis (TB) in children, and to identify if there is a relationship between these events with higher TB incidence and social determinants. Methods Ecological study carried out in Brazil. All cases of TB or unspecified pneumonia deaths in children under 5 years of […]
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Background The COVID‐19 pandemic lead scientists and governmental authorities to issue clinical and public health recommendations based on progressively emerging evidence and expert opinions and many of these fast‐tracked to peer‐reviewed publications. Concerns were raised on scientific quality and generalizability of this emerging evidence. Main argument However, this way acting is not entirely new and […]
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Hepatitis delta virus (HDV) is the agent responsible for the most severe form of human viral hepatitis. The HDV genome consists of a single‐stranded circular RNA molecule that encodes for one single protein, the delta antigen. Given its simplicity, HDV must make use of several host cellular proteins to accomplish its life cycle processes, including […]
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Major epidemics including some that qualify as pandemics, such as Severe Acute Respiratory Syndrome (SARS), Middle-Eastern Respiratory Syndrome (MERS), Human Immunodeficiency Virus, pandemic H1N1/09 and most recently COVID-19 affect the lung. Tuberculosis (TB) remains the top infectious disease killer but apart from the TB-HIV syndemic, little is known regarding the interaction of viral epidemics and […]
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RESUMO Introdução: As debilidades do sistema de saúde da Guiné-Bissau estão há muito sinalizadas. O objetivo deste estudo é contribuir com evidência para tomada de decisão sobre a reforma do mapa sanitário do país, pela análise à disponibilidade e prontidão de ser-viços das estruturas sanitárias que poderiam vir a integrar um complexo hospitalar em Bissau, […]
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Abstract Background The global financial crisis impacted public health in Europe, and had a particularly critical detriment to health systems in Southern Europe. We aim to describe HIV response and progress towards the current global HIV targets in specific Southern European countries, which received financial adjustment programmes. Methods We examined and compared a set of […]
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There is obvious interest in gaining insights into the epidemiology and evolution of the virus that has recently emerged in humans as the cause of the coronavirus disease 2019 (COVID-19) pandemic. The recent paper by Forster et al. analyzed 160 severe acute respiratory syndrome coronavirus (SARS-CoV-2) full genomes available (https://www.gisaid.org/) in early March 2020. The […]
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