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Home / Archives for 2015

2015

Policies to sustain the nursing workforce: an international perspective

  • Autores: Buchan J, Duffield C, Dussault G, Stone PW, Twigg D
  • Ano de Publicação: 2015
  • Journal: International Nursing Review
  • Link: http://onlinelibrary.wiley.com/doi/10.1111/inr.12169/abstract

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Dirofilariasis by Dirofilaria repens: an imported case and a brief review

  • Autores: Baptista-Fernandes T, Belo S, Domingues D, Mauricio I, Monteiro L, Paixao P, Pereira P, Rodrigues M, Rodrigues P, Tavares R, Toscano C
  • Ano de Publicação: 2015
  • Journal: Parasitology International
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25769814

Human infections caused by Dirofilaria repens, a cosmopolitan zoonotic parasitosis endemic in Southern and Eastern Europe and Asia still is an underdiagnosed infection due to parasite identification difficulties.
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Artificial feeding of Rhipicephalus microplus female ticks with anti calreticulin serum do not influence tick and Babesia bigemina acquisition

  • Autores: Antunes S, de la Fuente J, Domingos A, Domingues N, Lerias J, Merino O, Mosqueda J
  • Ano de Publicação: 2015
  • Journal: Ticks and Tick-Borne Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25262467

Ticks are obligate haematophagous ectoparasites considered the principal vectors of disease among animals. Rhipicephalus microplus and R. annulatus ticks are the most important vectors for Babesia bigemina and B. bovis, two of the most important intraerythrocytic protozoan parasites species in cattle, responsible for babesiosis which together with anaplasmosis account for substantial economic losses in the livestock industry worldwide.
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Global Dispersal Pattern of HIV Type 1 Subtype CRF01_AE: A Genetic Trace of Human Mobility Related to Heterosexual Sexual Activities Centralized in Southeast Asia

  • Autores: Albert J, Alexiev I, AM, Angelis K, Hamouda O, Hatzakis A, Magiorkinis G, Mamais I, Struck D, Vandamme, Vercauteren J, Wensing AMJ
  • Ano de Publicação: 2015
  • Journal: Journal of Infectious Diseases
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25512631

Human immunodeficiency virus type 1 (HIV-1) subtype CRF01_AE originated in Africa and then passed to Thailand, where it established a major epidemic. Despite the global presence of CRF01_AE, little is known about its subsequent dispersal pattern.
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Performance of an In-House Human Immunodeficiency Virus Type 1 Genotyping System for Assessment of Drug Resistance in Cuba

  • Autores: Abrahantes Y, Aleman Y, Alvarez A, AM, Correa C, Fonseca C, K, Kour V, Perez J, Perez L, Schrooten, Soto Y, Van Laethem, Vandamme, Vinken L, Y
  • Ano de Publicação: 2015
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324769/

As commercial human immunodeficiency virus type 1 drug resistance assays are expensive, they are not commonly used in resource-limited settings. Hence, a more affordable in-house procedure was set up taking into account the specific epidemiological and economic circumstances of Cuba. The performance characteristics of the in-house assay were evaluated using clinical samples with various subtypes and resistance patterns
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Lack of evidence for the selection of E138 mutations by first-generation non-nucleoside reverse transcriptase inhibitors in patients infected with HIV-1 non-B subtypes

  • Autores: Abecasis AB, Theys K, Van Laethem K
  • Ano de Publicação: 2015
  • Journal: Aids
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25909833

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Protein Disulfide Isomerases: Impact of Thapsigargin treatment on their expression in melanoma cell lines

  • Autores: Novo C, Silva Z, Veríssimo T, Videira PA
  • Ano de Publicação: 2015
  • Journal: IJBIOMAC
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25912252

Anti-cancer treatments usually elevate the content of unfolded or misfolded proteins in the endoplasmic reticulum (ER). Here we aimed to get insights into the relation between sensitivity of melanoma cell lines to the ER stress inducer thapsigargin (THG) and the genetic expression of protein disulfide isomerase family members (PDIs). The expression of PDIs was analysed by flow cytometry and real-time PCR.
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One-pot synthesis of dual-stimuli responsive hybrid PNIPAAm-chitosan microgels

  • Autores: Borges JP, Echeverria C, IFerreira I, Novo C, Pereira L, Robalo A, Soares P
  • Ano de Publicação: 2015
  • Journal: Materials and Design
  • Link: http://www.sciencedirect.com/science/article/pii/S0264127515302392

The incorporation of magnetic nanoparticles into poly(N-isopropylacrylamide) (PNIPAAm) and chitosan microgels gives rise to hybrid systems that combine the microgels swelling capacity with the interesting features presented in magnetic nanoparticles. The presence of chitosan that act as surfactant for magnetic nanoparticles provides a simplistic approach which allows the encapsulation of magnetic nanoparticles without any previous surface modification.
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Challenges in Antibody Development against Tn and Sialyl-Tn Antigens

  • Autores: Barbas A, Carrascal MA, Delannoy P, Loureiro LR, Novo C, Ramalho JS, Videira PA
  • Ano de Publicação: 2015
  • Journal: Biomolecules
  • Link: http://www.mdpi.com/2218-273X/5/3/1783

The carbohydrate antigens Tn and sialyl-Tn (STn) are expressed in most carcinomas and usually absent in healthy tissues. These antigens have been correlated with cancer progression and poor prognosis, and associated with immunosuppressive microenvironment. Presently they are used in clinical trials as therapeutic vaccination, but with limited success due to their low immunogenicity.
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Thermal and magnetic properties of iron oxide colloids: influence of surfactants

  • Autores: Borges J, Coutinho J, Echeverria C, Ferreira I, Lochte F, Novo C, Pereira L, Soares P
  • Ano de Publicação: 2015
  • Journal: Nanotechnology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26421876

Iron oxide nanoparticles (NPs) have been extensively studied in the last few decades for several biomedical applications such as magnetic resonance imaging, magnetic drug delivery and hyperthermia. Hyperthermia is a technique used for cancer treatment which consists in inducing a temperature of about 41-45 °C in cancerous cells through magnetic NPs and an external magnetic field. Chemical precipitation was used to produce iron oxide NPs 9 nm in size coated with oleic acid and trisodium citrate.
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