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Home / Archives for 2015

2015

Nested and Multiplex Real-Time PCR Using Dual-Labeled Probes: Detecting and Discriminating Mycobacterium tuberculosis Complex Members in Cultures and Animal Tissues

  • Autores: Costa P, Couto I, Inacio J, Viveiros M
  • Ano de Publicação: 2015
  • Journal: Methods in molecular biology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25399092

Members of the Mycobacterium tuberculosis complex (MTC) are causative agents of tuberculosis (TB) in both humans and animals. In the last two decades, the accumulating knowledge of the nucleotide sequences of several genes, and of the whole genomes, of MTC members has allowed the development of novel molecular assays able to detect and discriminate between these species.
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In Vitro Susceptibility of Leishmania infantum to Artemisinin Derivatives and Selected Trioxolanes

  • Autores: Albuquerque A, Cabral LIL, Campino L, Cortes S, Cristiano MLS, Lopes L
  • Ano de Publicação: 2015
  • Journal: Antimicrobial Agents and Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26014947

Leishmaniasis is among the world’s most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs.
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Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences

  • Autores: Alves A, Coll F, Guerra-Assunção JA, Hill-Cawthorne G, Mallard K, McNerney R, Miranda A, Nair M, Preston MD, Viveiros M, Warry A
  • Ano de Publicação: 2015
  • Journal: Genome Medicine
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26019726

Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease control. Current molecular tests examine limited numbers of mutations, and although whole genome sequencing approaches could fully characterise DR, data complexity has restricted their clinical application.
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Evaluation of salt content in school meals

  • Autores: Colaco Lourenco Viegas CA, Graca P, Oliveira Martins MdR, Torgal J
  • Ano de Publicação: 2015
  • Journal: Brazilian Journal of Nutrition
  • Link: http://www.scielo.br/scielo.php?pid=S1415-52732015000200165&script=sci_arttext

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Enhancement of antibiotic activity by efflux inhibitors against multidrug resistant Mycobacterium tuberculosis clinical isolates from Brazil

  • Autores: Coelho T, Couto I, Machado D, Maschmann R, Ramos D, Rossetti ML, Silva PA, Viveiros M, von Groll A
  • Ano de Publicação: 2015
  • Journal: Frontiers in Microbiology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25972842

Drug resistant tuberculosis continues to increase and new approaches for its treatment are necessary. The identification of M. tuberculosis clinical isolates presenting efflux as part of their resistant phenotype has a major impact in tuberculosis treatment. In this work, we used a checkerboard procedure combined with the tetrazolium microplate-based assay (TEMA) to study single combinations between antituberculosis drugs and efflux inhibitors (EIs) against multidrug resistant M. tuberculosis clinical isolates using the fully susceptible strain H37Rv as reference.
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Analysis of the sporozoite ELISA for estimating infection rates in Mozambican anophelines

  • Autores: Charlwood JD, Cuamba N, Pinto J, Tomas EVE
  • Ano de Publicação: 2015
  • Journal: Medical and Veterinary Entomology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25088021

Comparisons were undertaken to investigate cost-effective methods of implementing the enzyme-linked immunosorbent assay (ELISA) for sporozoite determination in anophelines when large numbers require processing.
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Hemisynthetic trifluralin analogues incorporated in liposomes for the treatment of leishmanial infections

  • Autores: Alexandra Esteves M, Armanda Rodrigues M, Carvalheiro M, Cruz MEM, Eleuterio CV, Lopes RM, Santos-Gomes G, Santos-Mateus D, Scoulica E
  • Ano de Publicação: 2015
  • Journal: European Journal of Pharmaceutics and Biopharmaceutics
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25936854

Leishmaniasis, a vector-borne parasitic disease caused by Leishmania protozoa, is one of the most neglected tropical diseases in terms of drug discovery and development. Current treatment is based on a limited number of chemotherapeutic agents all of which present either/or resistance issues, severe toxicities and adverse reactions associated with extended treatment regimens, and high cost of therapy.
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Negeviruses found in multiple species of mosquitoes from southern Portugal: Isolation, genetic diversity, and replication in insect cell culture

  • Autores: Abecasis A, Carapeta S, de Almeida APG, de Matos AP, do Bem B, Esteves A, Lopes A, McGuinness J, Parreira R, Piedade J
  • Ano de Publicação: 2015
  • Journal: Virology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26057025

In this report, an RT-PCR approach based on the use of degenerate primers allowed the identification of negeviruses in four different species of mosquitoes (Ochlerotatus caspius, Culex pipiens, Cx. theileri and Cx. univittatus) collected in southern Portugal. The genomes of two of these viruses, sequenced to full completion, were shown to encode all the proteins encoded by previously described negeviruses
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Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study

  • Autores: Cambau E, Hoffner S, Machado D, Matthys V, Perez Del Molino ML, Raskine L, Richter E, Ritter C, Tortoli E, Viveiros M
  • Ano de Publicação: 2015
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25587993

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Enhancing activity of antibiotics against Staphylococcus aureus: Zanthoxylum capense constituents and derivatives

  • Autores: Cabral V, Costa SS, Couto I, Duarte A, Ferreira M-JU, Junqueira E, Luo X, Mulhovo S, Viveiros M
  • Ano de Publicação: 2015
  • Journal: Phytomedicine
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25925969

Six compounds (1-6), isolated from the methanol extract of the roots of the African medicinal plant Zanthoxylum capense Thunb. (Rutaceae), and seven ester derivatives (7-13) were evaluated for their antibacterial activities and modulatory effects on the MIC of antibiotics (erythromycin, oxacillin, and tetracycline) and ethidium bromide (EtBr) against a Staphylococcus aureus reference strain (ATCC 6538). Using the same model, compounds 1-13 were also assessed for their potential as efflux pump inhibitors by a fluorometric assay that measures the accumulation of the broad range efflux pump substrate EtBr. Compounds 8 and 11 were further evaluated for their antibacterial, modulatory and EtBr accumulation effects against four additional S. aureus strains, which included two clinical methicillin-resistant S. aureus (MRSA) strains.
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