Common Medical and Statistical Problems: The Dilemma of the Sample Size Calculation for Sensitivity and Specificity Estimation
- Autores: M.Rosário Oliveira, Ana Subtil, Luzia Gonçalves
- Ano de Publicação: 2020
- Journal: "Mathematics - Special Issue - Applied Medical Statistics: Theory - Computation - Applicability"
- Link: https://www.mdpi.com/2227-7390/8/8/1258/htm
Abstract Sample size calculation in biomedical practice is typically based on the problematic Wald method for a binomial proportion, with potentially dangerous consequences. This work highlights the need of incorporating the concept of conditional probability in sample size determination to avoid reduced sample sizes that lead to inadequate confidence intervals. Therefore, new definitions are proposed […]