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Home / Archives for Cunha C

Cunha C

Proteomic changes in HEK-293 cells induced by hepatitis delta virus replication

  • Autores: Coelho AV, Cunha C, Mendes M, Pérez-Hernandez D, Vázquez J
  • Ano de Publicação: 2013
  • Journal: Journal of Proteomics
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23770296

Hepatitis delta virus (HDV) infection greatly increases the risk of hepatocellular carcinoma in hepatitis B virus chronically infected patients. HDV is highly dependent on host factors for accomplishment of the replication cycle. However, these factors are largely unknown and the mechanisms involved in the pathogenicity of the virus still remain elusive.
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The heterogeneous ribonuclear protein C interacts with the hepatitis delta virus small antigen.

  • Autores: Casaca A, Cunha C, da Cruz E Silva E, Fardilha M
  • Ano de Publicação: 2011
  • Journal: Virology Journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=The+heterogeneous+ribonuclear+protein+C+interacts+with+the+hepatitis+delta+virus+small+antigen

BACKGROUND:
Hepatitis delta virus (HDV) is considered to be a satellite virus of the Hepatitis B virus. The genome consists of a 1679 nt ssRNA molecule in which a single ORF was identified.
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In Vivo Interaction of the Hepatitis Delta Virus Small Antigen with the ELAV-Like Protein HuR.

  • Autores: Casaca A, Cunha C, da Cruz E Silva E, Fardilha M
  • Ano de Publicação: 2011
  • Journal: The open virology journal
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=In+vivo+interaction+of+the+hepatitis+delta+virus+small+antigen+with+the+ELAV-like+protein+HuR

The small and large delta antigens (S-HDAg and L-HDAg, respectively) represent two forms of the only protein encoded by the hepatitis delta virus (HDV) RNA genome. Consequently, HDV relies, at a large extent, on the host cell machinery for replication and transcription.
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Hepatitis delta virus infects the cells of hepadnavirus-induced hepatocellular carcinoma in woodchucks.

  • Autores: Cunha C, Freitas N, Gudima SO, Menne S, Salisse J, Toshkov I
  • Ano de Publicação: 2012
  • Journal: Hepatology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Hepatitis+delta+virus+infects+the+cells+of+hepadnavirus-induced+hepatocellular+carcinoma+in+woodchucks

Hepatitis delta virus (HDV) is a natural subviral agent of human hepatitis B virus (HBV). HDV enhances liver damage during concomitant infection with HBV. The molecular pathogenesis of HDV infection remains poorly understood. To advance our understanding of the relationship between HDV infection and liver cancer, it was determined whether HDV could infect in vivo the cells of hepadnavirus-induced hepatocellular carcinoma (HCC).
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Mutations selected in HIV-2-infected patients failing a regimen including atazanavir

  • Autores: Aleixo MJ, Camacho RJ, Cavaco-Silva J, Cunha C, Faria D, Gomes P, Goncalves MF, Valadas E, Van Laethem K, Vandamme AM
  • Ano de Publicação: 2013
  • Journal: Journal of Antimicrobial Chemotherapy
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/22977160

To investigate mutations selected in viruses from HIV-2-infected patients failing a highly active antiretroviral treatment (HAART) regimen including atazanavir/ritonavir.
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Development of mathematical models for the analysis of hepatitis delta virus viral dynamics

  • Autores: Cunha C, de Sousa BC
  • Ano de Publicação: 2010
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/20862328

BACKGROUND:
Mathematical models have shown to be extremely helpful in understanding the dynamics of different virus diseases, including hepatitis B. Hepatitis D virus (HDV) is a satellite virus of the hepatitis B virus (HBV).
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Virus and non-coding RNAs: stars in the host-virus interaction game

  • Autores: Cunha C, Quina AS, Tavanez J
  • Ano de Publicação: 2014
  • Journal: Future Virology
  • Link: http://www.futuremedicine.com/doi/abs/10.2217/fvl.14.84?journalCode=fvl

In the past few years, noncoding RNAs (ncRNAs) have emerged as key modulators of the transcriptional and post-transcriptional control of a variety of cellular processes such as development, signaling, homeostasis and oncogenesis. Like their host cells, many viruses produce ncRNAs.
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Detection of Wolbachia in Dirofilaria infected dogs in Portugal

  • Autores: Alho A, Belo S, Calado M, Carvalho LM, Cunha C, Ferreira CC, Landum M, Mauricio I, Meireles JS
  • Ano de Publicação: 2014
  • Journal: Veterinary Parasitology
  • Link: http://www.sciencedirect.com/science/article/pii/S0304401714003069

Wolbachia pipiens, an intracellular endosymbiont bacteria of filarial nematodes, has been implicated in the pathogenesis of filarial diseases, in particular in heavy Dirofilaria spp. infections. Antibiotic therapy (doxycycline) against Wolbachia has been proven to be suitable adjunct therapy, prior to adulticide treatment of canine dirofilariosis.
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Envelope Proteins Derived from Naturally Integrated Hepatitis B Virus DNA Support Assembly and Release of Infectious Hepatitis Delta Virus Particles

  • Autores: Cunha C, Freitas N, Gudima SO, Menne S
  • Ano de Publicação: 2014
  • Journal: Journal of Virology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/24623409

A natural subviral agent of human hepatitis B virus (HBV), hepatitis delta virus (HDV), requires only the envelope proteins from HBV in order to maintain persistent infection. HBV surface antigens (HBsAgs) can be produced either by HBV replication or from integrated HBV DNA regardless of replication. The functional properties of the integrant-generated HBsAgs were examined using two human hepatocellular carcinoma-derived cell lines, Hep3B and PLC/PRF/5, that contain HBV integrants but do not produce HBV virions and have no signs of HBV replication.
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Support of the Infectivity of Hepatitis Delta Virus Particles by the Envelope Proteins of Different Genotypes of Hepatitis B Virus

  • Autores: Abe K, Cunha C, Freitas N, Gudima SO, Menne S
  • Ano de Publicação: 2014
  • Journal: Journal of Virology
  • Link: http://jvi.asm.org/content/88/11/6255.abstract

This study examined how the envelope proteins of 25 variants of hepatitis B virus (HBV) genotypes A to I support hepatitis delta virus (HDV) infectivity. The assembled virions bore the same HDV ribonucleoprotein and differed only by the HBV variant-specific envelope proteins coating the particles. The total HDV yields varied within a 122-fold range. A residue Y (position 374) in the HDV binding site was identified as critical for HDV assembly.
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