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Home / Archives for Silveira H

Silveira H

Generation of an antibody that recognizes Plasmodium chabaudi cysteine protease (chabaupain-1) in both sexual and asexual parasite life cycle and evaluation of chabaupain-1 vaccine potential

  • Autores: Almeida AJ, Antunes S, Armada A, Custodio A, Domingos A, Gazarini M, Gonçalves LM, Rodrigues A, Rosário VE, Santos-Gomes G, Silveira H
  • Ano de Publicação: 2013
  • Journal: Experimental Parasitology
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/23830988

Malaria cysteine proteases have been shown to be immunogenic and are being exploited as serodiagnostic markers, drug and vaccine targets. Several Plasmodium spp. cysteine proteases have been described and the best characterized of these are the falcipains, a family of papain-family enzymes. Falcipain-2 and falcipain-3 act in concert with other proteases to hydrolyze host erythrocyte hemoglobin in the parasite food vacuole.
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Prevalence and risk factors of Plasmodium falciparum infections in pregnant women of Luanda, Angola.

  • Autores: Campos PA, Do Rosário VE, Silveira H, Valente B, Varandas L
  • Ano de Publicação: 2011
  • Journal: Tropical Medicine & International Health
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/21729222

Pregnant women are at increased risk of malaria, but in Angola, epidemiologic data from this group is almost inexistent. We conducted a cross-sectional study to determine the prevalence and risk factors of Plasmodium falciparum infections in 567 pregnant Angolan women living in Luanda province.
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Biological behavior of Trypanosoma cruzi stocks obtained from the State of Amazonas, Western Brazilian Amazon, in mice.

  • Autores: Barbosa Md, Ferreira LC, Guerra JA, Magalhaes LK, Monteiro WM, Oliveira JC, Silveira H, Toledo MJ
  • Ano de Publicação: 2012
  • Journal: Revista Da Sociedade Brasileira De Medicina Tropical
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Biological+behavior+of+Trypanosoma+cruzi+stocks+obtained+from+the+State+of+Amazonas%2C+Western+Brazilian+Amazon%2C+in+mice

INTRODUCTION:
The biological diversity of circulating Trypanosoma cruzi stocks in the Amazon region most likely plays an important role in the peculiar clinic-epidemiological features of Chagas disease in this area.
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Plasmodium falciparum infection in pregnant women attending antenatal care in Luanda, Angola.

  • Autores: Campos PA, Campos RB, Gonçalves L, Rosário VE, Silveira H, Valente B, Varandas L
  • Ano de Publicação: 2012
  • Journal: Revista Da Sociedade Brasileira De Medicina Tropical
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Plasmodium+falciparum+infection+in+pregnant+women+attending+antenatal+care+in+Luanda%2C+Angola

INTRODUCTION:
Malaria during pregnancy remains a serious public health problem. The aim of this study was to establish the prevalence and possible risk factors for malaria in pregnant women attending antenatal care at Augusto Ngangula Specialized General Hospital in Luanda, Angola.
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Trypanosoma cruzi IV causing outbreaks of acute Chagas disease and infections by different haplotypes in the Western Brazilian Amazonia.

  • Autores: Barbosa Md, Borges L, de Sá AR, Gomes ML, Guerra JA, Magalhaes LK, Monteiro WM, Pires I, Silveira H, Toledo MJ
  • Ano de Publicação: 2012
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/?term=Trypanosoma+cruzi+IV+Causing+Outbreaks+of+Acute+Chagas+Disease+and+Infections+by+Different+Haplotypes+in+the+Western+Brazilian+Amazonia.

BACKGROUND:
Chagas disease is an emergent tropical disease in the Brazilian Amazon Region, with an increasing number of cases in recent decades. In this region, the sylvatic cycle of Trypanosoma cruzi transmission, which constitutes a reservoir of parasites that might be associated with specific molecular, epidemiological and clinical traits, has been little explored. The objective of this work is to genetically characterize stocks of T. cruzi from human cases, triatomines and reservoir mammals in the State of Amazonas, in the Western Brazilian Amazon.
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Chagas disease in the State of Amazonas: history, epidemiological evolution, risks of endemicity and future perspectives

  • Autores: Bemfica Barbosa Ferreira JM, Costa Magalhaes LK, de Oliveira Guerra JA, Fe NF, Goncalves Santana RA, Lima Arcanjo AR, Monteiro WM, Mota DT, Silveira H, Vale Barbosa MdG
  • Ano de Publicação: 2015
  • Journal: Revista Da Sociedade Brasileira De Medicina Tropical
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26061368

Chagas disease (CD) is a parasitic infection that originated in the Americas and is caused by Trypanosoma cruzi. In the last few years, the disease has spread to countries in North America, Asia and Europe due to the migration of Latin Americans. In the Brazilian Amazon, CD has an endemic transmission, especially in the Rio Negro region, where an occupational hazard was described for piaçaveiros (piassaba gatherers).
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Hemozoin activates the innate immune system and reduces Plasmodium berghei infection in Anopheles gambiae

  • Autores: Gonçalves L, Silveira H, Simoes ML
  • Ano de Publicação: 2015
  • Journal: Parasites & Vectors
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/25573379

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Unravelling the Evolution of the Allatostatin-Type A, KISS and Galanin Peptide-Receptor Gene Families in Bilaterians: Insights from Anopheles Mosquitoes

  • Autores: Cardoso JCR, Felix RC, Fonseca VG, Martins RS, Pires IRP, Power DM, Silveira H, Trindade M
  • Ano de Publicação: 2015
  • Journal: PLoS One
  • Link: http://www.ncbi.nlm.nih.gov/pubmed/26135459

Allatostatin type A receptors (AST-ARs) are a group of G-protein coupled receptors activated by members of the FGL-amide (AST-A) peptide family that inhibit food intake and development in arthropods. Despite their physiological importance the evolution of the AST-A system is poorly described and relatively few receptors have been isolated and functionally characterised in insects.
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Trypanosoma cruzi strain Tcl is associated with chronic Chagas disease in the Brazilian Amazon

  • Autores: Barbosa MDV, Barbosa-Ferreira JM, Coelho LIDRC, da Silva GAV, de Brito FR, Guerra JAO, Maciel MG, Magalhaes LK, Magalhaes LKC, Monteiro WM, Prestes SR, Santana RAG, Silveira H
  • Ano de Publicação: 2014
  • Journal: Parasites & Vectors
  • Link: http://www.parasitesandvectors.com/content/7/1/267

The aim of this study was to characterize Trypanosoma cruzi in patients with chronic Chagas disease in the State of Amazonas, Brazil.
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Anopheles gambiae eicosanoids modulate Plasmodium berghei survival from oocyst to salivary gland invasion

  • Autores: Custodio A, Ramos S, Silveira H
  • Ano de Publicação: 2014
  • Journal: Memorias do Instituto Oswaldo Cruz
  • Link: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156460/

Eicosanoids affect the immunity of several pathogen/insect models, but their role on the Anopheles gambiae response to Plasmodium is still unknown. Plasmodium berghei-infected mosquitoes were injected with an eicosanoid biosynthesis inhibitor, indomethacin (IN), or a substrate, arachidonic acid (AA), at day 7 or day 12 post-infection (p.i.).
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