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Instituto de Higiene e Medicina Tropical

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2014

Prevalence of Leptospira antibodies in wild boars (Sus scrofa) from Northern Portugal: risk factor analysis

Leptospirosis is a zoonosis of worldwide distribution, caused by infection with pathogenic spirochaetes of the genus Leptospira. The wild boar (Sus scrofa), an important hunting species in Europe, seems to play a significant role in the epidemiological cycle of leptospirosis. A total of 101 serum samples from wild boar hunted in Northern Portugal were analysed for leptospiral antibodies detection by microscopic agglutination test.
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Skill mix between physicians and nurses in Portugal: Legal barriers to change

Knowing that the legal framework that regulates each of these professions can hinder the review of their respective scope of practice, we assessed the need to change the Portuguese law in order to allow adjustments in nursing staff tasks’ boundaries.
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The future of novel diagnostics in medical mycology

Several fungal diseases have become serious threats to human health and life, especially upon the advent of human immunodeficiency virus/AIDS epidemics and of other typical immunosuppressive conditions of modern life. Accordingly, the burden posed by these diseases and, concurrently, by intensive therapeutic regimens against these diseases has increased worldwide.
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Virus and non-coding RNAs: stars in the host-virus interaction game

In the past few years, noncoding RNAs (ncRNAs) have emerged as key modulators of the transcriptional and post-transcriptional control of a variety of cellular processes such as development, signaling, homeostasis and oncogenesis. Like their host cells, many viruses produce ncRNAs.
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Larvicidal, molluscicidal and nematicidal activities of essential oils and compounds from Foeniculum vulgare

Plant-based products, namely essential oils (EOs), are environmentally friendly alternatives for the control of disease vectors, hosts and/or parasites. Here, we studied the general toxicity and biopesticidal potential of EOs and phenylpropanoids from Foeniculum vulgare var. vulgare (bitter fennel), a perennial plant well adapted to temperate climates.
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Iron oxide colloids: a comparative study of different surfactants

Iron oxide nanoparticles are having been extensively investigated for several biomedical applications such as hyperthermia and magnetic resonance imaging. However, one of the biggest problems of these nanoparticles is their aggregation. Taking this into account, in this study the influence of three different surfactants (oleic acid, sodium citrate and Triton X-100) each one with various concentrations in the colloidal solutions stability was analyzed by using a rapid and facile method, the variation in the optical absorbance along time.
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Transmission Potential of Antimony-Resistant Leishmania Field Isolates

We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies.
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First Report of Thelazia Callipaeda in red foxes (Vulpes Vulpes) from Portugal

The first cases of infection with the eyeworm Thelazia callipaeda (Spirurida, Thelaziidae) in red foxes (Vulpes vulpes) from Portugal are described. Worms were collected from 1 fox (7 worms) in the north and from 2 foxes (10 worms) in the central region of the country.
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Immunization with the Leishmania infantum recombinant cyclophilin protein 1 confers partial protection to subsequent parasite infection and generates specific memory T cells

Control of zoonotic visceral leishmaniosis can be achieved using several available drugs. These drugs present high toxicity and require longer treatment regimens which complicate compliance to the treatment. Other control measures directed to the vector or the reservoirs are useful tools to restrain the spreading of this disease but the effects are transitory.
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